New role for L-arginine in regulation of inducible nitric-oxide-synthase-derived superoxide anion production in Raw 264.7 macrophages

0372522 - BFÚ 2012 RIV US eng J - Článek v odborném periodiku
Pekarová, Michaela - Lojek, Antonín - Martíšková, Hana - Vašíček, Ondřej - Binó, Lucia - Klinke, A. - Lau, D. - Kuchta, R. - Kadlec, J. - Vrba, R. - Kubala, Lukáš
New role for L-arginine in regulation of inducible nitric-oxide-synthase-derived superoxide anion production in Raw 264.7 macrophages.
Scientific World Journal. Roč. 11, - (2011), s. 2443-2457. ISSN 1537-744X
Grant CEP: GA ČR(CZ) GA524/08/1753
Výzkumný záměr: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Klíčová slova: macrophages * L-arginine * inducible nitric oxide synthase
Kód oboru RIV: BO - Biofyzika
Impakt faktor: 1.524, rok: 2010

We demonstrated that simultaneous induction of NADPH oxidase, together with the iNOS enzyme, can result in the uncoupled state of iNOS resulting in the production of functionally important levels of superoxide anion soon after macrophage activation with LPS. Moreover, we demonstrated, for the first time that increased concentrations of L-arginine further potentiate iNOS-dependent superoxide anion in inflammatory macrophages.
Trvalý link: http://hdl.handle.net/11104/0205822