New polyene macrolide family produced by submerged culture of Streptomyces durmitorensis

0371872 - MBÚ 2012 RIV JP eng J - Článek v odborném periodiku
Stodůlková, Eva - Kuzma, Marek - Hench, I. B. - Černý, J. - Králová, Jarmila - Novák, Petr - Chudíčková, Milada - Savic, M. - Djokic, L. - Vasiljevic, B. - Flieger, Miroslav
New polyene macrolide family produced by submerged culture of Streptomyces durmitorensis.
Journal of Antibiotics. Roč. 64, č. 11 (2011), s. 717-722. ISSN 0021-8820. E-ISSN 1881-1469
Grant CEP: GA MŠMT 2B08064
Výzkumný záměr: CEZ:AV0Z50200510; CEZ:AV0Z50520514
Klíčová slova: apoptosis * FTMS * polyene macrolide
Kód oboru RIV: EE - Mikrobiologie, virologie
Impakt faktor: 1.651, rok: 2011

A new polyene macrolide family, closely related to the pentaene macrolide antibiotic roflamycoin, was isolated from the both fermentation broth and biomass of Streptomyces durmitorensis wild-type strain MS405. The main compound was identified by NMR and Fourier transform ion cyclotron resonance mass spectrometry as 32,33-didehydroroflamycoin (1; DDHR). Additional four structurally related compounds were determined solely by MS analysis. DDHR induces cell death by apoptosis in various cancer cell lines as demonstrated by DNA fragmentation. Striking feature of DDHR is its internal fluorescence allowing visualization of labeled plasma membranes and internal membrane structures
Trvalý link: http://hdl.handle.net/11104/0205290