Reaction of prion protein with quinacrine

0370683 - ÚOCHB 2012 CZ eng C - Konferenční příspěvek (zahraniční konf.)
Zawada, Zbigniew - Šafařík, Martin - Šebestík, Jaroslav - Stibor, Ivan - Bouř, Petr
Reaction of prion protein with quinacrine.
Biologically Active Peptides. 12th Conference. Praha: Institute of Organic Chemistry and Biochemistry AS CR, v. v. i, 2011 - (Slaninová, J.), s. 163-165. Collection Symposium Series, 13. ISBN 978-80-86241-44-9.
[Biologically Active Peptides /12./. Praha (CZ), 27.04.2011-29.04.2011]
Grant CEP: GA ČR GA203/07/1517
Výzkumný záměr: CEZ:AV0Z40550506
Klíčová slova: prion protein * quinacrine * transition state calculation * activation energy prediction
Kód oboru RIV: CC - Organická chemie

Prion protein is supposed to cause Creutzfeld–Jakob disease, which can be treated in cell culture by quinacrine. In this work we study acridinylation reaction of prion protein. We also investigate this reaction theoretically on simple models and calculate activation energies for a large ensemble of acridine derivatives. Found correlation between the reactivity and geometry can enhance the design of the new acridine compounds, particularly for medical purposes.
Trvalý link: http://hdl.handle.net/11104/0204408