Fmoc deprotection by tert-butylamine and its comparison in solution and solid phase synthesis

0370529 - ÚOCHB 2012 CZ eng C - Konferenční příspěvek (zahraniční konf.)
Flegel, Martin - Flegelová, Z. - Maloň, Petr - Klenerová, V. - Hynie, S.
Fmoc deprotection by tert-butylamine and its comparison in solution and solid phase synthesis.
Biologically Active Peptides. 12th Conference. Praha: Institute of Organic Chemistry and Biochemistry AS CR, v. v. i, 2011 - (Slaninová, J.), s. 41-44. Collection Symposium Series, 13. ISBN 978-80-86241-44-9.
[Biologically Active Peptides /12./. Praha (CZ), 27.04.2011-29.04.2011]
Grant CEP: GA AV ČR(CZ) KAN200520703; GA AV ČR KAN200100801
Výzkumný záměr: CEZ:AV0Z40550506
Klíčová slova: tert-Butylamine (TBA) * Fmoc deprotection * oxytocin cycle * CD spectra
Kód oboru RIV: CC - Organická chemie

tert-Butylamine was employed as the alternative to piperidine for Fmoc deprotection in liquid and solid phase peptide synthesis. Basic kinetic parameters of deprotecting reaction were checked in chosen Fmoc amino acid derivatives. Solid phase synthesis of cyclic part of oxytocin (tocinamide) was worked out and used for CD spectra measurement.
Trvalý link: http://hdl.handle.net/11104/0204314