Počet záznamů: 1
Early postnatal development of rat brain is accompanied by generation of lipofuscin-like pigments
- 1.0365079 - FGÚ 2012 RIV US eng J - Článek v odborném periodiku
Wilhelm, J. - Ivica, J. - Kagan, Dmytro - Svoboda, Petr
Early postnatal development of rat brain is accompanied by generation of lipofuscin-like pigments.
Molecular and Cellular Biochemistry. Roč. 347, 1-2 (2011), s. 157-162. ISSN 0300-8177. E-ISSN 1573-4919
Grant CEP: GA MŠMT(CZ) LC554; GA AV ČR(CZ) IAA500110606
Výzkumný záměr: CEZ:AV0Z50110509
Klíčová slova: brain * early development * lipofuscin-like pigments * fluorescence * rat
Kód oboru RIV: CE - Biochemie
Impakt faktor: 2.057, rok: 2011
The increased generation of free radicals results in the formation of fluorescent end-products of lipid peroxidation, lipofuscin-like pigments (LFPs). The authors observed that LFPs are generated in rat brain after a normal birth during 5 postnatal days. Maximum LFP concentration is achieved on the postnatal day 2. Starting from postnatal day 10, LFP concentration returns to prenatal values. A new rise in LFP concentration is observed at 3 months of age. This is associated with the beginning of the aging process. The authors suggest that LFPs are formed after respiratory burst of microglia phagocytosing apoptotic cells
Trvalý link: http://hdl.handle.net/11104/0200414
Počet záznamů: 1