Počet záznamů: 1
Role of the Ectodomain Serine 275 in Shaping the Binding Pocket of the ATP-Gated P2X3 Receptor
- 1.0365067 - FGÚ 2012 RIV US eng J - Článek v odborném periodiku
Petrenko, N. - Khafizov, K. - Tvrdoňová, Vendula - Skorinkin, A. - Giniatullin, R.
Role of the Ectodomain Serine 275 in Shaping the Binding Pocket of the ATP-Gated P2X3 Receptor.
Biochemistry. Roč. 50, č. 39 (2011), s. 8427-8436. ISSN 0006-2960. E-ISSN 1520-4995
Grant ostatní: Univerzita Karlova(CZ) 3446/2011
Výzkumný záměr: CEZ:AV0Z50110509
Klíčová slova: P2X3 * purinergic * ATP * ATP-binding pocket * receptor
Kód oboru RIV: ED - Fyziologie
Impakt faktor: 3.422, rok: 2011
In this work, by exploring in silico the functional role for the left flipper located in the ectodomain region, we identified within this loop a candidate residue S275, which could contribute to the closure of the agonist-binding pocket. Testing of the S275 mutants using the patch-clamp technice revealed a crucial role for S275 in agonist binding and receptor desensitization
Trvalý link: http://hdl.handle.net/11104/0200403
Počet záznamů: 1