Počet záznamů: 1
The role of human cytochrome P4503A4 in biotransformation of tissue-specific derivatives of 7H-dibenzo[c,g]carbazole
- 1.0365057 - ÚEM 2012 RIV US eng J - Článek v odborném periodiku
Mesárošová, M. - Valovičová, Z. - Srančíková, A. - Krajčovičová, Z. - Milcová, Alena - Sokolová, Romana - Schmuczerová, Jana - Topinka, Jan - Gábelová, A.
The role of human cytochrome P4503A4 in biotransformation of tissue-specific derivatives of 7H-dibenzo[c,g]carbazole.
Toxicology and Applied Pharmacology. Roč. 255, č. 3 (2011), s. 307-315. ISSN 0041-008X. E-ISSN 1096-0333
Grant CEP: GA MŠMT 2B08005
Výzkumný záměr: CEZ:AV0Z50390512; CEZ:AV0Z40400503; CEZ:AV0Z50040507
Klíčová slova: cytochrome P4503A4 * 7H-dibenzo[c,g]carbazole * Hprt gene mutations
Kód oboru RIV: DN - Vliv životního prostředí na zdraví
Impakt faktor: 4.447, rok: 2011
http://arl-repository.lib.cas.cz/uloziste_av/UEM-P/cav_un_epca-0365057_01.pdf
The environmental pollutant 7H-dibenzo[c,g]carbazole (DBC) and its derivative, 5,9-dimethylDBC (DiMeDBC), produced significant and dose-dependent levels of micronuclei followed by a substantial increase in the frequency of apoptotic cells in the V79MZh3A4 cell line stably expressing the human cytochrome P450 (hCYP) 3A4. In contrast, neither micronuclei nor apoptosis were found in cells exposed to the sarcomagenic carcinogen, N-methylDBC (N-MeDBC). Based on our results, we suggest that hCYP3A4 is involved in the metabolism of DBC and its tissue-specific derivatives. While hCYP3A4 probably plays an important role in biotransformation of the liver carcinogens, DBC and DiMeDBC, it might only have a marginal function in N-MeDBC metabolism.
Trvalý link: http://hdl.handle.net/11104/0200393
Počet záznamů: 1