Počet záznamů: 1
Acyclic Nucleoside Phosphonates as Inhibitors of Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase: New Anti-Malarial Chemotherapy Leads
- 1.0361115 - ÚOCHB 2012 CZ eng C - Konferenční příspěvek (zahraniční konf.)
Hocková, Dana - Holý, Antonín - Česnek, Michal - Baszczyňski, Ondřej - Tichý, Tomáš - Krečmerová, Marcela - Janeba, Zlatko - Skinner-Adams, T. S. - Naesens, L. - Keough, D. T. - de Jersey, J. - Guddat, L. W.
Acyclic Nucleoside Phosphonates as Inhibitors of Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase: New Anti-Malarial Chemotherapy Leads.
Chemistry of Nucleic Acid Components. 15th Symposium. Praha: Institute of Organic Chemistry and Biochemistry AS CR, v. v. i., 2011 - (Hocek, M.), s. 171-174. Collection Symposium Series, 12. ISBN 978-80-86241-37-1.
[Chemistry of Nucleic Acid Components /15./. Český Krumlov (CZ), 05.06.2011-10.06.2011]
Grant CEP: GA MŠMT 1M0508; GA ČR GAP207/11/0108
Výzkumný záměr: CEZ:AV0Z40550506
Klíčová slova: ANPs * acyclic nucleoside phosphonates * anti-malarial * Plasmodium * HGXPRTase
Kód oboru RIV: CC - Organická chemie
Hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRTase) is a widely recognized target for the discovery of new anti-malarial drugs. Specific acyclic nucleoside phosphonates (ANPs) inhibit HGXPRTase and possess anti-plasmodial activity. Within the framework of a SAR-study, the classical ANPs (e.g. PME-, PMP- and HPMP-derivatives) as well as novel series of compounds were tested to investigate their efficiency and selectivity on the inhibition of P. falciparum, P. vivax and human enzyme.
Trvalý link: http://hdl.handle.net/11104/0198518
Počet záznamů: 1