Počet záznamů: 1
3-Fluoro-2-(phosphonomethoxy)propyl hypoxanthine and guanine derivatives as inhibitors of plasmodial hypoxanthine-guanine-xanthine phosphoribosyltransferases
- 1.0361105 - ÚOCHB 2012 CZ eng C - Konferenční příspěvek (zahraniční konf.)
Baszczyňski, Ondřej - Jansa, Petr - Hocková, Dana - Janeba, Zlatko - Dračínský, Martin - Holý, Antonín - Keough, D. T. - de Jersey, J. - Guddat, L. W.
3-Fluoro-2-(phosphonomethoxy)propyl hypoxanthine and guanine derivatives as inhibitors of plasmodial hypoxanthine-guanine-xanthine phosphoribosyltransferases.
Chemistry of Nucleic Acid Components. 15th Symposium. Praha: Institute of Organic Chemistry and Biochemistry AS CR, v. v. i., 2011 - (Hocek, M.), s. 302-303. Collection Symposium Series, 12. ISBN 978-80-86241-37-1.
[Chemistry of Nucleic Acid Components /15./. Český Krumlov (CZ), 05.06.2011-10.06.2011]
Grant CEP: GA MŠMT 1M0508; GA ČR GAP207/11/0108
Výzkumný záměr: CEZ:AV0Z40550506
Klíčová slova: ANPs * acyclic nucleoside phosphonates * anti-malarial * plasmodium * HGXPRTase
Kód oboru RIV: CC - Organická chemie
A new methodology for the synthesis of ANPs containing 9-[2-(phosphonoethoxy)ethyl] (PEE) moiety has been developed. FPEP compound containing guanine moiety exhibited inhibition activity against the enzyme in micromolar range without any signs of toxicity.
Trvalý link: http://hdl.handle.net/11104/0198511
Počet záznamů: 1