Počet záznamů: 1
Age-related autocrine diabetogenic effects of transgenic resistin in spontaneously hypertensive rats: gene expression profile analysis
- 1.0359445 - FGÚ 2012 RIV US eng J - Článek v odborném periodiku
Pravenec, Michal - Zídek, Václav - Landa, Vladimír - Šimáková, Miroslava - Mlejnek, Petr - Šilhavý, J. - Maxová, M. - Kazdová, L. - Seidman, J. G. - Seidman, Ch. E. - Eminaga, S. - Gorham, J. - Wang, J. - Kurtz, T. W.
Age-related autocrine diabetogenic effects of transgenic resistin in spontaneously hypertensive rats: gene expression profile analysis.
Physiological Genomics. Roč. 43, č. 7 (2011), s. 372-379. ISSN 1094-8341. E-ISSN 1531-2267
Grant CEP: GA MŠMT(CZ) ME08006; GA MŠMT(CZ) 1M0510; GA AV ČR(CZ) IAA500110805; GA MZd(CZ) NS9759
Grant ostatní: Fondation Leducq(FR) 06CVD03
Výzkumný záměr: CEZ:AV0Z50110509
Klíčová slova: transgenic rat * adipose tissue * insulin resistance * autocrine effects
Kód oboru RIV: FB - Endokrinologie, diabetologie, metabolizmus, výživa
Impakt faktor: 2.735, rok: 2011
We investigated potential autocrine effects of resistin on lipid and glucose metabolism in 2- and 16-mo-old transgenic spontaneously hypertensive rats (SHR) expressing a nonsecreted form of mouse resistin under control of the aP2 promoter. Our results suggest that with increasing age autocrine effects of resistin in fat tissue may predispose to diabetes in part by impairing insulin action in adipose tissue
Trvalý link: http://hdl.handle.net/11104/0197234
Počet záznamů: 1