Počet záznamů: 1
Influence of Non-Natural Amino Acids at Position 3 of [Mpa1, D-Tyr(Et)2] or [Mpa1, D-1-Nal2] Oxytocin on Their Pharmacological Properties
- 1.0356808 - ÚOCHB 2011 DK eng C - Konferenční příspěvek (zahraniční konf.)
Magafa, V. - Assimomytis, N. - Pairas, G. - Exarchakou, R. K. - Daletos, G. K. - Borovičková, Lenka - Slaninová, Jiřina - Cordopatis, P.
Influence of Non-Natural Amino Acids at Position 3 of [Mpa1, D-Tyr(Et)2] or [Mpa1, D-1-Nal2] Oxytocin on Their Pharmacological Properties.
Peptides 2010: Tales of Peptides. Proceedings of the Thirty-First European Peptide Symposium. Copenhagen: European Peptide Society, 2010 - (Lebl, M.; Meldal, M.; Jensen, K.; Hoeg-Jensen, T.), s. 448-449. ISBN 0-9715560-5-9.
[Peptides 2010: Tales of Peptides. Proceedings of the European Peptide Symposium /31./. Copenhagen (DK), 05.09.2010-09.09.2010]
Výzkumný záměr: CEZ:AV0Z40550506
Klíčová slova: oxytocin * analogues * position 3 * L-1-Nal * D-1-Nal
Kód oboru RIV: CC - Organická chemie
We synthesized 8 new analogues of potent oxytocin antagonists containing L-/D-1-naphtylalanine or L-/D-allylglycine in position 3. Their pressor and uterotonic aktivity was determined as well as their binding affinity to oxytocin receptors.
Trvalý link: http://hdl.handle.net/11104/0195236
Počet záznamů: 1