Počet záznamů: 1
[2+2+2]-Cocyclotrimerization of 6-Alkynyl-7-benzylpurines with alpha, omega-Diynes
- 1.0356369 - ÚOCHB 2011 RIV JP eng J - Článek v odborném periodiku
Opekar, S. - Turek, P. - Pohl, Radek - Klepetářová, Blanka - Votruba, Ivan - Hocek, Michal - Kotora, M.
[2+2+2]-Cocyclotrimerization of 6-Alkynyl-7-benzylpurines with alpha, omega-Diynes.
Heterocycles. Roč. 82, č. 1 (2010), s. 895-907. ISSN 0385-5414. E-ISSN 1881-0942
Grant CEP: GA MŠMT 1M0508
Výzkumný záměr: CEZ:AV0Z40550506
Klíčová slova: cyclotrimerization * purine * alkyne * nickel * catalysis
Kód oboru RIV: CC - Organická chemie
Impakt faktor: 1.093, rok: 2010
6-Alkynyl-7-benzylpurines were prepared by the Sonogashira reaction from 6-chloro-7-benzylpurines and terminal alkynes. The prepared alkynylpurines were cyclotrimerized with various 1,6-diynes in the presence of Ni(cod)2/2PPh3 catalytic system into the corresponding 6-aryl-7-benzylpurines under ambient conditions. The prepared 6-alkynyl- and 6-aryl-7-benzylpurines were tested for cytostatic activity.
Trvalý link: http://hdl.handle.net/11104/0194908
Počet záznamů: 1