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STIM1-Directed Reorganization of Microtubules in Activated Mast Cells
- 1.0355825 - ÚMG 2011 RIV US eng J - Článek v odborném periodiku
Hájková, Zuzana - Bugajev, Viktor - Dráberová, Eduarda - Vinopal, Stanislav - Dráberová, Lubica - Janáček, Jiří - Dráber, Petr - Dráber, Pavel
STIM1-Directed Reorganization of Microtubules in Activated Mast Cells.
Journal of Immunology. Roč. 186, č. 2 (2011), s. 913-923. ISSN 0022-1767. E-ISSN 1550-6606
Grant CEP: GA ČR(CZ) GD204/09/H084; GA ČR GA204/09/1777; GA ČR GA301/09/1826; GA ČR GAP302/10/1759; GA MŠMT LC545; GA MŠMT(CZ) LC06063; GA AV ČR KAN200520701
Výzkumný záměr: CEZ:AV0Z50520514; CEZ:AV0Z50110509
Klíčová slova: STIM1 * bonemarrow-derived mast cells * microtubules
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 5.788, rok: 2011
This research article shows important role of STIM1 protein in activation of bone marrow-derived mast cells. During activation process, mast cells change intracellular level of calcium and present microtubule reorganization. The molecular mechanisms for control microtubule rearrangement during activation events are still unknown. Activation of mast cells results in generation of microtubule protrusions that are calcium dependent. Experiments with knockdown or reexpression of STIM1 protein, the key regulator of store-operated calcium entry, confirmed the important role of STIM1 in the formation of protrusions. This article propose that calcium plays an important role in the formation of microtubule protrusions in mast cells and that rearrangement of microtubules in activated mast cells depends on STIM1-induced calcium entry.
Trvalý link: http://hdl.handle.net/11104/0194505
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