Polychromatic immunophenotyping and probability binning algorithm reveal distinct disease clusters in patients with Common Variable Immunodeficiency

0355242 - BTÚ 2011 eng C - Konferenční příspěvek (zahraniční konf.)
Kalina, T. - Stuchlý, J. - Janda, A. - Hrušák, O. - Růžičková, Šárka - Šedivá, A. - Litzman, J. - Vlková, M.
Polychromatic immunophenotyping and probability binning algorithm reveal distinct disease clusters in patients with Common Variable Immunodeficiency.
Abstracts of 2nd European Congress of Immunology, Immunity for Life, Immunity for Health. Wiley-Blackwell, 2009, ---. ISSN 0014-2980. E-ISSN 1521-4141.
[2nd European Congress of Immunology: Immunity for Life, Immunity for Health. Berlín (DE), 13.09.2009 – 16.09. 2009]
Výzkumný záměr: CEZ:AV0Z50520701
Klíčová slova: probability binning * B lymphocyte subsets * common variable immunodeficiency * B lymphocyte profiling * clusters
Kód oboru RIV: EC - Imunologie

New CD21-CD38-CD27-CD24+IgM+ and CD21-CD38- CD27-CD24-IgM+ subpopulations of B lymphocytes were shown using molecular analysis to display the signs of antigen-driven selection, affinity maturation and isotype switching in both patients with immunodeficiences and controls. These populations can be easily identified using so-called binning algorithm allowing generation of clusters of patients and B lymphocyte subsets. The validity of this method was verified using classical flow cytometry gating and correlation between flow cytometry data and clinical parameters
Trvalý link: http://hdl.handle.net/11104/0194058