Počet záznamů: 1
2’- and 5’-Phosphonate oligoadenylates: Novel effectors of RNase L
- 1.0353426 - ÚOCHB 2011 FR eng C - Konferenční příspěvek (zahraniční konf.)
Páv, Ondřej - Panova, Natalya - Snášel, Jan - Rosenberg, Ivan
2’- and 5’-Phosphonate oligoadenylates: Novel effectors of RNase L.
International Roundtable on Nucleosides, Nucleotides and Nucleic Acids. IRT 2010. Lyon: Université de Lyon, 2010, s. 197-198.
[International Roundtable on Nucleosides, Nucleotides and Nucleic Acids. IRT 2010. Lyon (FR), 29.08.2010-03.09.2010]
Grant CEP: GA MŠMT(CZ) LC06077; GA MŠMT(CZ) LC06061; GA AV ČR KAN200520801
Výzkumný záměr: CEZ:AV0Z40550506
Klíčová slova: phosphonate oligonucleotides * RNase L * oligoadenylate analogs
Kód oboru RIV: CC - Organická chemie
http://irt2010.univ-lyon1.fr
Two sets of phosphonate oligoadenylate analogues, modified with either 2´- or 5´-phosphonate unit, were synthesized and their ability to bind to, and activate, human RNase L was evaluated. Several potent effectors of this enzyme were selected, and structure-activity data obtained.
Trvalý link: http://hdl.handle.net/11104/0192678
Počet záznamů: 1