Implications of Altered Gene Expression in Embryo and Placenta during Diabetic Pregnancy

0351895 - BTÚ 2011 US eng A - Abstrakt
Kappen, C. - Pavlínková, Gabriela - Kruger, C. - Salbaum, M.
Implications of Altered Gene Expression in Embryo and Placenta during Diabetic Pregnancy.
Birth Defects Research Part A-Clinical and Molecular Teratology. Roč. 85, č. 5 (2009), s. 410-410. ISSN 1542-0752
Výzkumný záměr: CEZ:AV0Z50520701
Klíčová slova: Embryopathy * microarrays * placenta
Kód oboru RIV: EB - Genetika a molekulární biologie

Diabetes during pregnancy is a known risk factor for congenital malformations of the cardiovascular system and for neural tube defects. Using genome-wide expression prolifing, we have shown that the exposure is associated with deregulated gene expression in the developing embryo. Altered gene expression was also evident in the diabetic placenta, where a different repertoire of genes is misexpressed. This indicates that responses to metabolic imbalance employ specific pathways in tissue- and cell-type-specific manner, thus implicating multiple and distinct gene-environment interactions in birth defects risk under conditions of diabetic pregnancy.
Trvalý link: http://hdl.handle.net/11104/0191537