Počet záznamů: 1
HPMA copolymer conjugates of paclitaxel and docetaxel with pH-controlled drug release
- 1.0346325 - ÚMCH 2011 RIV US eng J - Článek v odborném periodiku
Etrych, Tomáš - Šírová, Milada - Starovoytova, Larisa - Říhová, Blanka - Ulbrich, Karel
HPMA copolymer conjugates of paclitaxel and docetaxel with pH-controlled drug release.
Molecular Pharmaceutics. Roč. 7, č. 4 (2010), s. 1015-1026. ISSN 1543-8384. E-ISSN 1543-8392
Grant CEP: GA MŠMT 1M0505; GA AV ČR IAAX00500803
Výzkumný záměr: CEZ:AV0Z40500505; CEZ:AV0Z50200510
Klíčová slova: N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer * docetaxel * paclitaxel
Kód oboru RIV: CD - Makromolekulární chemie
Impakt faktor: 5.400, rok: 2010
In this paper we describe the synthesis, physicochemical characteristics and data on the biological activity of polymer prodrugs based on the anticancer drugs paclitaxel (PTX) and docetaxel (DTX) conjugated with a water-soluble N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer drug carrier. The drugs were derivatized and then attached to the polymer backbone via a spacer that is stable under physiological conditions (pH 7.4) and hydrolytically degradable in mild acidic environments (e.g., endosomes, pH similar to 5).
Trvalý link: http://hdl.handle.net/11104/0005970
Počet záznamů: 1