0342527 - FGÚ 2011 RIV US eng J - Článek v odborném periodiku
Petretto, E. - Bottolo, L. - Langley, S. R. - Heinig, M. - McDermott-Roe, Ch. - Sarwar, R. - Pravenec, Michal - Hübner, N. - Aitman, T. J. - Cook, S.A. - Richardson, S.
New Insights into the Genetic Control of Gene Expression using a Bayesian Multi-tissue Approach.
PLoS Computational Biology. Roč. 6, č. 4 (2010), e1000737. ISSN 1553-734X. E-ISSN 1553-7358
Grant CEP: GA ČR(CZ) GA301/08/0166; GA MŠMT(CZ) 1M0520; GA ČR GAP301/10/0290
Grant ostatní: EC(XE) LSHG-CT-2005-019015; Fondation Leducq(FR) 06 CVD 03
Výzkumný záměr: CEZ:AV0Z50110509
Klíčová slova: expression profiles * Bayesian multi-tissue approach * genetical genomics
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 5.515, rok: 2010 ; AIS: 2.979, rok: 2010
DOI: https://doi.org/10.1371/journal.pcbi.1000737

To uncover complex genetic regulatory mechanisms controlling gene expression at the whole organism’s level, it is essential to develop appropriate analytical methods for the analysis of genome-wide genetic polymorphisms and gene expression profiles simultaneously in multiple tissues. This paper presents a novel, fully integrated Bayesian approach for mapping the genetic components of gene expression within and across multiple tissues
Trvalý link: http://hdl.handle.net/11104/0185241