Počet záznamů: 1
The effect of flavonoid derivatives on doxorubicin transport and metabolism
- 1.0340042 - ÚMG 2010 RIV GB eng J - Článek v odborném periodiku
Václavíková, R. - Kondrová, E. - Ehrlichová, Marie - Boumendjel, A. - Kovář, Jan - Stopka, Pavel - Souček, P. - Gut, I.
The effect of flavonoid derivatives on doxorubicin transport and metabolism.
Bioorganic & Medicinal Chemistry. Roč. 16, č. 4 (2008), s. 2034-2042. ISSN 0968-0896. E-ISSN 1464-3391
Výzkumný záměr: CEZ:AV0Z40320502; CEZ:AV0Z50520514
Klíčová slova: Doxorubicin * Quercetin * Flavonoids * P-Glycoprotein
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 3.075, rok: 2008
This study investigated the effect of naturally occurring flavonoids and synthetic aurone derivatives on the formation of cardiotoxic doxorubicinol and transport of doxorubicin in breast cancer cells. Quercetin significantly inhibited the formation of doxorubicinol. Quercetin and aurones did not significantly affect transport of doxorubicin in human resistant breast cancer cells. In conclusion, quercetin should be further tested for its potency to decrease doxorubicin-mediated toxicity.
Trvalý link: http://hdl.handle.net/11104/0183369
Počet záznamů: 1