Melatonin: Biological Basis of Its Function in Health and Disease

0339690 - FGÚ 2010 RIV US eng M - Část monografie knihy
Zemková, Hana - Balík, Aleš - Stojilkovič, S.S.
Expression and Signal Transduction Pathways of Melatonin Receptors in the Pituitary.
Melatonin: Biological Basis of Its Function in Health and Disease. Georgetown: Eurekah.com, 2006 - (Pandi-Perumal, S.; Cardinali, D.), s. 88-104. ISBN 1-58706-244-5
Grant CEP: GA AV ČR IAA5011105; GA AV ČR IAA5011103
Výzkumný záměr: CEZ:AV0Z50110509
Klíčová slova: melatonin * gonadotropin-releasing hormone * anterior pituitary
Kód oboru RIV: ED - Fyziologie

Pituitary cells from neonatal animals express functional MT1 subtype of melatonin receptors that are coupled to pertussis toxin-sensitive G proteins. Their activation by melatonin leads to a decrease in cAMP production, intracellular calcium, activity of protein kinase A, and attenuation of gonadotropin-releasing hormone (GnRH)-induced gonadotropin secretion
Trvalý link: http://hdl.handle.net/11104/0183137