Thyroid hormones modulate occurrence and termination of ventricular fibrillation by both long-term and acute actions

0338076 - FGÚ 2010 RIV CZ eng J - Článek v odborném periodiku
Knezl, V. - Soukup, Tomáš - Okruhlicová, L. - Slezák, J. - Tribulová, N.
Thyroid hormones modulate occurrence and termination of ventricular fibrillation by both long-term and acute actions.
[Tyroidní hormony ovlivňují výskyt síňové fibrilace v akutním i chronickém pokusu.]
Physiological Research. Roč. 57, Suppl.2 (2008), S91-S96. ISSN 0862-8408. E-ISSN 1802-9973
Grant CEP: GA ČR(CZ) GA304/05/0327
Výzkumný záměr: CEZ:AV0Z50110509
Klíčová slova: ventricular fibrillation * sinus rhythm restoration * thyroid hormone
Kód oboru RIV: ED - Fyziologie
Impakt faktor: 1.653, rok: 2008

The T4 treatment resulted in an increased susceptibility of young, but not adult rat hearts to a hypokalemia-induced VF and facilitated a spontaneous sinus rhythm (SSR) restoration in the latter group. The acute T3 administration of in the range of 10-9-10-7 mol/l significantly decreased the susceptibility of an isolated heart to an electrically induced VF and also facilitated the sinus rhythm restoration. The SSR restoration was, however, not affected by 10-6 mol/l concentration of T3, which in addition, led to an increased VF susceptibility. Results indicate that TH can affect the susceptibility of the heart to VF and its ability to restore the sinus rhythm via fast acute (non-genomic) and long lasting chronic (genomic) actions. Furthermore, an anti- and pro-arrhythmic potential of TH appears to be age- and dose-dependent

Naše výsledky ukazují, že tyroidní hormony ovlivňují citlivost srdce k síňové fibrilaci stejně jako schopnost obnovit rytmus a to jak akutními tak i dlouhotrvajícími vlivy
Trvalý link: http://hdl.handle.net/11104/0181939