Nuclear receptor NHR-25 interacts with Wnt/β-catenin signaling to direct differentiation of the C. elegans T cell

0336504 - BC 2010 RIV US eng A - Abstrakt
Hajdušková, Martina - Jindra, Marek - Herman, M. A. - Asahina, Masako
Nuclear receptor NHR-25 interacts with Wnt/β-catenin signaling to direct differentiation of the C. elegans T cell.
Developmental Biology. Elsevier. Roč. 331, č. 2 (2009), s. 513-514. ISSN 0012-1606. E-ISSN 1095-564X.
[Annual Meeting of the Society for Developmental Biology /68./. 23.07.2009-27.07.2009, San Francisco]
Grant CEP: GA ČR(CZ) GA204/07/0948; GA ČR(CZ) GD204/09/H058; GA MŠMT 2B06129
Výzkumný záměr: CEZ:AV0Z60220518; CEZ:AV0Z50070508
Klíčová slova: Caenorhabditis elegans * asymmetric cell divisions * cell differentiation
Kód oboru RIV: EB - Genetika a molekulární biologie

We show that an impaired function of the nuclear receptor NHR-25 abolishes differentiation of the neural T cell lineage similarly to mutations in Wnt/β-catenin asymmetry signaling pathwaycomponents. By means of genetic interactionwe demonstrate that NHR-25 cooperates with the Wnt/β-catenin pathway and with a parallel RUNX signaling to establish the correct fate of T cell daughters. Strikingly, the positive interaction between NHR-25 and Wnt/ catenin signaling in the T cell has an opposite character than in the C. elegans somatic gonad, where NHR-25 was shown to antagonize a β-catenin pathway.
Trvalý link: http://hdl.handle.net/11104/0180721