Počet záznamů: 1
Selective Inhibition of Casein Kinase 1 epsilon Minimally Alters Circadian Clock Period
- 1.0328977 - FGÚ 2010 RIV US eng J - Článek v odborném periodiku
Walton, K. M. - Fisher, K. - Rubitski, D. - Marconi, M. - Meng, Q.-J. - Sládek, Martin - Adams, J. - Bass, M. - Chandrasekaran, R. - Butler, T. - Griffor, M. - Rajamohan, F. - Serpa, M. - Chen, Y. - Claffey, M. - Hastings, M. - Loudon, A. - Maywood, E. - Ohren, J. - Doran, A. - Wager, T. T.
Selective Inhibition of Casein Kinase 1 epsilon Minimally Alters Circadian Clock Period.
Journal of Pharmacology and Experimental Therapeutics. Roč. 330, č. 2 (2009), s. 430-439. ISSN 0022-3565. E-ISSN 1521-0103
Výzkumný záměr: CEZ:AV0Z50110509
Klíčová slova: circadian clock * casein kinase 1 epsilon * inhibitor
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 4.093, rok: 2009
Casein kinases 1 (CK1) epsilon and delta mutations have dramatic effect on circadian clock period. We have previously shown, that pan-CK1delta/epsilon inhibitor causes a delay in animal models of circadian rhythm, however it remains unclear, whether one of the kinases has predominant role. Here we have used novel selective CK1 epsilon inhibitor to show that wild-type CK1 epsilonhas only minimal effect on circadian clock relative to CK1 delta
Trvalý link: http://hdl.handle.net/11104/0175143
Počet záznamů: 1