Seminal plasma and sperm surface proteins in reproduction

0326012 - BTÚ 2010 CZ eng A - Abstrakt
Jonáková, Věra - Postlerová, Pavla - Davidová, Nina - Tichá, M. - Šutovský, P. - Pěknicová, Jana
Seminal plasma and sperm surface proteins in reproduction.
Sborník - XV. Symposium českých reprodukčních imunologů s mezinárodní účastí. Praha: BTO-N, 2009. s. 31-32.
[XV. Symposium českých reprodukčních imunologů s mezinárodní účastí. 29.05.2009-31.05.2009, Žďár nad Sázavou]
Grant CEP: GA MŠMT(CZ) 1M06011; GA ČR GA303/09/1285; GA ČR GD523/08/H064
Výzkumný záměr: CEZ:AV0Z50520701
Klíčová slova: sperm surface protein * ubiqutin C-terminal hydrolase * boar spermadhesin * AQN 1 * boar seminal plasma
Kód oboru RIV: EC - Imunologie

Boar seminal plasma (SP) protein AQN 1 spermadhesin binds to the sperm plasma membrane that overlies the outer acrosomal membrane and has been implicated in sperm binding to the zona pellucida (ZP) as well as in sperm interactions with the epithelium of the oviductal sperm reservoir. Human SP was found to be very low in AQN 1 spermadhesin–like proteins. Ubiquitin C-terminal hydrolases (UCHs) are responsible for the removal of polyubiquitin chains during protein priming for proteasomal proteolysis. Modulation of UCH activity could facilitate the management of polyspermy during IVF and provide insight into male infertility. Boar sperm UCHL3 was localized to the acrosomal surface and coimmunoprecipitated with boar AQN 1 spermadhesin.
Trvalý link: http://hdl.handle.net/11104/0173255