Effect of endocrine disruptors on mammalian fertility

0323271 - BTÚ 2011 BG eng C - Konferenční příspěvek (zahraniční konf.)
Pěknicová, Jana - Nováková, Vendula - Buckiová, Daniela - Boubelík, Michael
Effect of endocrine disruptors on mammalian fertility.
Scientific session - dedicated to the 70th anniversary of the Institute of Biology and Immunology of Reproduction. Sofia: Bulgarian Academy of Scientes, 2008, s. 1-75.
[Scientific session dedicated to the 70th Anniversary of the Institute of biology and Immunology of Reproduction. Sofia (BG), 23.10.2008]
Grant CEP: GA MŠMT(CZ) EUREKA OE211; GA MŠMT(CZ) 1M06011; GA MŠMT(CZ) 2B06151
Výzkumný záměr: CEZ:AV0Z50520701
Klíčová slova: endocrine disruptor * fertility * spermatozoa
Kód oboru RIV: DN - Vliv životního prostředí na zdraví

Endocrine system is one of the most important regulatory systems in the mammalian body. The endocrine disruptors (ED) can disrupt the function of the endocrine system but their activity is not a result of the physiological regulation. The effect of low dose of selected ED, bisphenol-A (BPA), p-nonylphenol (NP), diethylstilbestrol (DES), genistein (GEN), resveratrol (RES)), hormone (17α-ethynylestradiol (EE2)) and polybrominated compound (tetrabromobisphenol A (TBBPA)) within development of reproductive tract in outbred CD1 mice was tested. BPA and NP had a negative effect on reproductive organs morphology and mouse spermatozoa. The fertility of mice exposed to DES was disrupted. Contrary to that, treatment by GEN and RES had no effect on the fertility of mice but had some effect on their reproductive parameters except for sperm integrity. Synthetic hormone (EE2) and polybrominated compound (TBBPA) also affected on the organ weight, reproductive parameters and sperm quality.
Trvalý link: http://hdl.handle.net/11104/0171277