Embryogenesis of the heart muscle

0316944 - ÚŽFG 2009 RIV US eng J - Článek v odborném periodiku
Sedmera, David - McQuinn, T. C.
Embryogenesis of the heart muscle.
[Embryogeneze srdečního svalu.]
Heart Failure Clinics. Roč. 4, - (2008), s. 235-245. ISSN 1551-7136
Grant ostatní: National Institutes of Health(US) C06 RR16434; National Institutes of Health(US) C06 RR018823; AV ČR(CZ) Purkyně Fellowship
Výzkumný záměr: CEZ:AV0Z5045916
Klíčová slova: heart development * myocardium * microscopy
Kód oboru RIV: FA - Kardiovaskulární nemoci vč. kardiochirurgie

Myocardium is derived from precardiac mesoderm, and its formation is subject of positive and negative regulation by a number of genes. After formation of a tubular heart with a mode of contraction distinct from subsequent stages, initial increase in ventricular mass during the period of chamber formation is achieved by development of trabeculations, a hallmark of sponge-like hearts. Similar structures (pectinate muscles) develop later on in the atria. Trabecular compaction coincides with deployment of coronary circulation, and results in formation of ventricular chambers with significant, vascularized compact layers and clearly delineated lumen, which are capable of superior performance (pressure generation, ejection fraction) than the avascular, spongy ventricles. The contraction of the developing heart is orchestrated by its pacemaking and conduction system, which develops and changes parallel to heart morphogenesis. While the molecular determination of the sinoatrial node and atrioventricular was recently unraveled, the pathways implicated in induction and patterning of ventricular His-Purkinje system are still subject to research.

Přehledný článek popisující vývoj architektury myokardu za vývoje a postup diferenciace převodního systému. Cílovou skupinou jsou dětští a dospělí kardiologové.
Trvalý link: http://hdl.handle.net/11104/0166716