The Lack of Correlation between the Increased Frequency of Allele IL-1RN*2 of Interleukin-1 Receptor Antagonist Gene in Czech Patients with Knee Osteoarthritis and the Markers of Cartilage Degradation

0312726 - BTÚ 2010 RIV CZ eng J - Článek v odborném periodiku
Růžičková, Šárka - Šenolt, L. - Gatterová, J. - Vencovský, J. - Pavelka, K.
The Lack of Correlation between the Increased Frequency of Allele IL-1RN*2 of Interleukin-1 Receptor Antagonist Gene in Czech Patients with Knee Osteoarthritis and the Markers of Cartilage Degradation.
Folia Biologica. Roč. 54, č. 4 (2008), s. 115-120. ISSN 0015-5500. E-ISSN 0015-5500
Výzkumný záměr: CEZ:AV0Z50520701
Klíčová slova: knee osteoarthritis * IL-1RN gene * VNTR polymorphism
Kód oboru RIV: EC - Imunologie
Impakt faktor: 1.140, rok: 2008

Fifty patients with primary knee osteoarthritis (OA) and 170 healthy controls were tested in order to determine whether the IL-1RN*2 allele could be a factor predisposing to development of knee OA in general and/or whether it could correlate with the markers of cartilage destruction, additionally affecting the course and severity of the disease. The results suggest that the IL-1RN*2 allele might represent a factor of susceptibility to OA generally; however, no correlation between this allele and the markers of cartilage degradation was found.
Trvalý link: http://hdl.handle.net/11104/0163712