The effect of pH on peroxidase-mediated oxidation of and DNA adduct formation by ellipticine

0305574 - ÚOCHB 2008 CZ eng J - Článek v odborném periodiku
Poljaková, J. - Dračínský, Martin - Frei, E. - Hudeček, J. - Stiborová, M.
The effect of pH on peroxidase-mediated oxidation of and DNA adduct formation by ellipticine.
[Vliv pH na peroxidasovou oxidaci elipticinu a tvorbu aduktů s DNA.]
Collection of Czechoslovak Chemical Communications. Roč. 71, č. 8 (2006), s. 1169-1185. ISSN 0010-0765
Klíčová slova: ellipticine * anticancer drugs * peroxidases
Kód oboru RIV: CC - Organická chemie
Impakt faktor: 0.881, rok: 2006

We investigated the effect of pH on the efficiency of three model peroxidases in oxidation of ellipticine and in formation ellipticine-DNA adducts. The formation of the major ellipticine metabolite, ellipticine dimmer and formation of four ellipticine-DNA adducts were analyzed. The results presented here are a contribution to the explanation of the reaction mechanism of formation of the major deoxyguanosine adduct in DNA generated from ellipticine in vivo and in vitro by its activation with cytochromes P450 and peroxidases.

Byl studován vliv pH na peroxidasovou oxidaci elipticinu a tvorbu aduktů s DNA. Pro tvorbu dimeru elipticinu bylo nalezeno pH optimum 6.4 a pro tvorbu aduktů s DNA ph 8.4.
Trvalý link: http://hdl.handle.net/11104/0158819