Chromosome Condensation in Pig Oocytes: Lack of a requirement for Either cdc2 Kinase or MAP Kinase Activity

0213511 - UZFG-Y 20023127 RIV US eng J - Článek v odborném periodiku
Kubelka, Michal - Anger, Martin - Kalous, Jaroslav - Schultz, R. M. - Motlík, Jan
Chromosome Condensation in Pig Oocytes: Lack of a requirement for Either cdc2 Kinase or MAP Kinase Activity.
Molecular Reproduction and Development. Roč. 63, - (2002), s. 110-118. ISSN 1040-452X. E-ISSN 1098-2795
Grant CEP: GA ČR GA203/99/1459; GA AV ČR KSK5052113
Grant ostatní: GA XE(XE) QLRT-1999-00104
Klíčová slova: GVBD * chromosome condensation * okadaic acid
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 2.322, rok: 2002

In this study, butyrolactone I (BL I), a potent and specific inhibitor of cyclin-dependent kinases (cdk), is shown to inhibit germinal vesicle breakdown (GVBD) in pig oocytes. Results suggest that both chromosome condensation and GVBD could occur without activation of cdc2 kinase, whereas an increase in MAP kinase activity may be a requisite for GVBD in pig oocytes in conditions when cdc2 kinase activation is blocked by BL I.
Trvalý link: http://hdl.handle.net/11104/0109047