Voltage clamp analysis of ajmaline-induced block of potassium currents in ventricular myocytes

0212193 - UT-L 20020139 RIV CZ eng C - Konferenční příspěvek (zahraniční konf.)
Bahníková, M. - Matějovič, P. - Pásek, Michal - Šimurdová, M. - Šimurda, J.
Voltage clamp analysis of ajmaline-induced block of potassium currents in ventricular myocytes.
Analysis of biomedical signals and images. Brno: University of Technology VUTIUM Press, 2002 - (Jan, J.; Kozumplík, J.; Provazník, I.), s. 217-219. ISBN 80-214-2633-0. ISSN 1211-412X.
[Biosignal 2002. Brno (CZ), 26.06.2002-28.06.2002]
Výzkumný záměr: CEZ:AV0Z2076919
Klíčová slova: cardiac cell * potassium currents * ajmaline
Kód oboru RIV: BO - Biofyzika

This study was aimed to analyze the effects of the antiarrhythmic drug ajmaline (a known inhibitor of the fast sodium current INa) on the potassium currents, namely the transient outward current (Ito) and the current measured at the end of a depolarizing pulse (IK) in rat ventricular myocytes. Both currents were inhibited in concentration- and voltage-dependent manner. However, the effects were frequency-independent.
Trvalý link: http://hdl.handle.net/11104/0107741