Quantitative modelling of interaction of propafenone with sodium channels in cardiac cells

0211857 - UT-L 20010109 RIV HR eng C - Konferenční příspěvek (zahraniční konf.)
Pásek, Michal - Šimurda, J.
Quantitative modelling of interaction of propafenone with sodium channels in cardiac cells.
Mediterranean Conference on Medical and Biological Engineering and Computing. Pula: Faculty of Electrical Engineering, Zagreb, 2001 - (Magjarevič, R.; Tonkovič, S.; Bilas, V.; Lackovič, I.), s. 1028-1031. Part. ISBN 953-184-024-5. ISSN 1680-0737.
[Mediterranean Conference on Medical and Biological Engineering and Computing /9./. Pula (HR), 12.06.2001-15.06.2001]
Grant ostatní: ÚT AV ČR(XC) PP52018
Klíčová slova: cardiac cell * propafenone * quantitative modelling
Kód oboru RIV: BO - Biofyzika

A mathematical model of the interaction of propafenone with sodium channels is based on experimental data that demonstrate use dependent effect of the drug. Transitions among channel states are described by a kinetic diagram and a corre-sponding set of differential equations. The values of rate constants of the drug-receptor reaction are fitted to experimental data by repeated computer simulations using a genetic algorithm. The model suggests the following interpretation of the obtained experimental
Trvalý link: http://hdl.handle.net/11104/0107406