Determination of confidence regions of model parameters in mono- and biexponential fitting of relaxation curves

0205704 - UPT-D 20030087 RIV CA eng C - Konferenční příspěvek (zahraniční konf.)
Starčuk jr., Zenon - Starčuková, Jana
Determination of confidence regions of model parameters in mono- and biexponential fitting of relaxation curves.
Proceedings of the International Sociaty for Magnetic Resonance in Medicine - 11th Scientific Meeting and Exhibition. Toronto: ISMRM, 2003, s. 1102.
[ISMRM 2003. Toronto (CA), 10.07.2003-16.07.2003]
Grant CEP: GA ČR GA202/02/1493
Výzkumný záměr: CEZ:AV0Z2065902
Klíčová slova: relaxation curves * relaxation times * confidence regions
Kód oboru RIV: JA - Elektronika a optoelektronika, elektrotechnika

Various MRI and MRS data sets acquired by relaxation-sensitive measurements were analyzed with the aim to assess the relaxation parameters. Considerable sensitivity of these parameters to the setup of the algorithm used to minimize the quadratic error of mono- or biexponential models was often found. Bad conditioning was identified as the principal cause, rather than the minimizing algorithm or noise alone. Interpretation of mode parameters should take the inherent uncertainty into account. Simulated and real data were used to study the shape and extent of the confidence regions including those model parameter sets that are consistent with the data measured.
Trvalý link: http://hdl.handle.net/11104/0101317