0193809 - UOCHB-X 20000241 RIV US eng C - Konferenční příspěvek (zahraniční konf.)
Slaninová, Jiřina - Machová, Alena - Ikeo, T. - Ueki, M.
The effect of disulfide bond replacement by a methylenedithioether bond on the biological activity of oxytocin and deaminooxytocin.
Proceedings of the 16th American Peptide Symposium. Peptides for the New Millennium. Boston: Kluwer, 2000 - (Fields, G.; Tam, J.; Barany, G.), s. 632-633. ISBN 0-7923-6445-7.
[Peptides for the New Millennium. American Peptide Symposium /16./. Minneapolis (US), 26.06.1999-01.07.1999]
Grant CEP: GA AV ČR KSK2055603
Výzkumný záměr: CEZ:AV0Z4055905
Kód oboru RIV: CE - Biochemie

The synthesis and biological properties of two new oxytocin analogs having stable methylenedithioether bonds in place of the S-S bridge, isosteric to the oxytocin trisulfides, are described. The activities of the analogs having -S-carba-S-bridge are decreased in comparison to that of oxytocin in all tests by the factor 10-50. Their activity is about 2 fold lower than the activity of the appropriate trisulfide analogs.
Trvalý link: http://hdl.handle.net/11104/0089501