Numerous binding sites for angiotensin iv and LVV-Hemorfin-7 on HT115 colorectal carcinoma cells

0191689 - UMG-J 20033204 RIV GR eng C - Konferenční příspěvek (zahraniční konf.)
Železná, Blanka - Sovová, Vlasta - Kučerová, Dana - Šloncová, Eva - Velek, Jiří - Hradilek, Martin - Slaninová, Jiřina - Zórad, Š.
Numerous binding sites for angiotensin iv and LVV-Hemorfin-7 on HT115 colorectal carcinoma cells.
7th world Congress on Advances in Oncology and 5 th International Symposium on Molecular Medicine. Kréta, Řecko: Řecko, 2002, s. -.
[World Congress on Advances in Oncology /7./ and International Symposium on Molecular Medicine /5./. Řecko (GR), 10.10.2002-12.10.2002]
Výzkumný záměr: CEZ:AV0Z4055905; CEZ:AV0Z5052915
Klíčová slova: Numerous binding * sites for angiotensin * LVV-hemorfin-7
Kód oboru RIV: EB - Genetika a molekulární biologie

For angiotensin IV (Ang IV), angiotensin II 3-8 fragment, its specific receptor was described in brain and kidney). In brain, Ang IV is scarce, LVV-hemorfin-7, an opioid decapeptide of hemoglobin, was found there as the AT4 receptor was identified as insulin regulated amino poptidase and Ang IV and LVV-hemorfin-7 as IRAP inhibitors. We propose that numerous And IV binding sites and high IRAP expression on HT 115 colorectal carcinoma line and their decrease ofter butyrate differentiation point to AT4/IRAP as a potential cencer marker.
Trvalý link: http://hdl.handle.net/11104/0087426