Isochore conservation between MHC regions on human chromosome 6 and mouse chromosome 7

0191423 - UMG-J 20010495 RIV NL eng J - Článek v odborném periodiku
Pavlíček, Adam - Clay, O. - Jabbari, K. - Pačes, Jan - Bernardi, G.
Isochore conservation between MHC regions on human chromosome 6 and mouse chromosome 7.
FEBS Letters. Roč. 511, 1-3 (2002), s. 175-177. ISSN 0014-5793. E-ISSN 1873-3468
Grant CEP: GA MŠMT LN00A079
Klíčová slova: isochores * MHC region * human genome
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 3.912, rok: 2002

It is shown that the structure of the MHC system on the mouse chromosomes 17 and 6 is conserved at the level of chromosome synteny and organization of homologous genes, as well as at the isochore structure level i.e., GC content in larger chromosome regions. Despite a much lower retrotransposon content in mouse MHC, their distribution is conserved i.e., B1 and Alu in GC-rich and LINE1 in GC-poor regions.
Trvalý link: http://hdl.handle.net/11104/0087176