Caveolae are involved in the trafficing of mouse polyomavirus virions and artificial VP1 pseudocapsids toward cell nuclei

0191323 - UMG-J 20010393 RIV US eng J - Článek v odborném periodiku
Richterová, Z. - Liebl, D. - Horák, M. - Palková, Z. - Štokrová, Jitka - Hozák, Pavel - Korb, Jan - Forstová, J.
Caveolae are involved in the trafficing of mouse polyomavirus virions and artificial VP1 pseudocapsids toward cell nuclei.
Journal of Virology. Roč. 75, č. 22 (2001), s. 10880-10891. ISSN 0022-538X. E-ISSN 1098-5514
Grant CEP: GA ČR GA204/00/0271; GA MŠMT VS96130
Grant ostatní: HHMI(US) 75195-540501
Klíčová slova: polyomavirus internalization * VP1 pseudocapsids * caveolae
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 5.622, rok: 2001

Colocalization of VP1 with caveolin-1 was observed during viral particle movement from the plasma membrane throughout the cytoplasm to the perinuclear area. Microfilaments decorated by the VP1 immunofluorescent signal could be seen as concentric curves, apparently along membrane structures that probably represent endoplasmic reticulum. However, the vast majority of VP1 pseudocapsids did not enter the nuclei.
Trvalý link: http://hdl.handle.net/11104/0087078