DNA vaccination against v-src oncogene-induced tumours in congenic chicken

0191227 - UMG-J 20010298 RIV GB eng J - Článek v odborném periodiku
Plachý, Jiří - Hejnar, Jiří - Trtková, Kateřina - Trejbalová, Kateřina - Svoboda, Jan - Hála, K.
DNA vaccination against v-src oncogene-induced tumours in congenic chicken.
Vaccine. Roč. 19, - (2001), s. 4526-4535. ISSN 0264-410X. E-ISSN 1873-2518
Grant CEP: GA ČR GA524/99/0366; GA AV ČR IPP2052002
Výzkumný záměr: CEZ:AV0Z5052915
Klíčová slova: v-src-specific immunity * DNA vaccination * chicken MHC (B)
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 2.943, rok: 2001

We have evaluated the protective activity of v-src-derived DNA vaccines against growth of tumors. Convincing protection against oncogenic v-src challenge was obtained in congenic chicken line CB (a regressor line od v-src-induced tumors). In the CC congenic chicken line (regressors of v-src-induced tumors) we observed tumor growth retardation after a low-dose DNA vaccination administered to immature recipients while higher amounts of DNA vaccine in immunocompetent chickens exerted an enhancing effect.
Trvalý link: http://hdl.handle.net/11104/0086984