Expression of hypoxia-inducible cell-surface transmembrane carbonic anhydrases in human cancer

0191208 - UMG-J 20010279 RIV US eng J - Článek v odborném periodiku
Ivanov, S. - Shu-Yuan, L. - Ivanova, A. - Danilkovitch-Miagkova, A. - Tarasova, N. - Weirich, G. - Merrill, M. J. - Proescholdt, M. A. - Oldfield, E. H. - Lee, J. - Závada, Jan - Waheed, A. - Sly, W. - Lerman, M. I. - Stanbridge, E. J.
Expression of hypoxia-inducible cell-surface transmembrane carbonic anhydrases in human cancer.
American Journal of Pathology. Roč. 158, č. 3 (2001), s. 905-919. ISSN 0002-9440. E-ISSN 1525-2191
Grant CEP: GA ČR GA301/99/0356
Výzkumný záměr: CEZ:AV0Z5052915
Klíčová slova: carbonic anhydrase 9 * hypoxia * human cancer
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 7.103, rok: 2001

We analyzed the experssion of carbonic anhydrase CA9 and CA12genes in a large sample of cancer cell lines, fresh and archival cell specimens, and normal human tissues. Expression of CA9 and CA12 in normal adult tissues was detected only in highly specialized cells and their expression did not overlap. In Von Hippel-Lindau (VHL)-defective tumors and/or under hypoxic conditions, CA9 and CA12 genes are overexpressed. We suggest that expression of CA9 and CA12 may be required for tumor progression.
Trvalý link: http://hdl.handle.net/11104/0086965