Reduced phagocytic activity of polymorphonuclear lekocytes in ŕ(1,3) fucosyltransferase VII-deficient mice

0191183 - UMG-J 20010253 RIV DK eng J - Článek v odborném periodiku
Bartůňková, J. - Malý, Petr - Smetana Jr., K. - Šedivá, A. - Klubal, R. - Mayerová, D. - Sedláček, A. - Šplíchalová, V.
Reduced phagocytic activity of polymorphonuclear lekocytes in ŕ(1,3) fucosyltransferase VII-deficient mice.
Acta Pathologica Microbiologica et Immunologica Scandinavica. Roč. 108, č. 6 (2000), s. 409-416. ISSN 0903-4641. E-ISSN 1600-0463
Grant CEP: GA ČR GA301/97/0234
Grant ostatní: GA UK(XC) 177/98
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 1.713, rok: 2000

We studied immune parameters in alfa(1,3)fucosyltransferaseVII -/- mice. Leukocytes were tested for adherence to cellophane membranes or polymer particles in vivo and phagocytic activity in vitro. While no difference in adherence was found, the reduced number of Fuc-TVII -/- neutrophils in exudate induced by i.p. infection of polymer beads and lower phagocytic activity were found. The -/- mice have splenomegaly, increased hematopoiesis and reduced weight but do not exhibit clinical signs of immunodeficiency.
Trvalý link: http://hdl.handle.net/11104/0086940