Human tumour-associated cell adhesion protein MN/CA IX: identification of M75 epitopes and of the region mediating cell adhesion

0190947 - UMG-J 20000043 RIV GB eng J - Článek v odborném periodiku
Závada, Jan - Závadová, Zuzana - Pastorek, J. - Biesova, Z. - Ježek, Jan - Velek, Jiří
Human tumour-associated cell adhesion protein MN/CA IX: identification of M75 epitopes and of the region mediating cell adhesion.
British Journal of Cancer. Roč. 82, č. 11 (2000), s. 1808-1813. ISSN 0007-0920. E-ISSN 1532-1827
Grant CEP: GA ČR GA301/99/0356; GA AV ČR KSK2039602
Grant ostatní: GA SK(SK) 2/4103/98
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 3.489, rok: 2000

Using a series of synthetic oligopeptides, we identified the epitope of MN/CA IX protein for monoclonal antibody M75 - it is PGEEDLP. This epitope ovelaps with the binding site for cell surface receptors. From phage display library of random heptapetideswe identified and synthesized those which compete for epitope with M75 and inhibit adhesion capacity of MN/CA IX for cells.
Trvalý link: http://hdl.handle.net/11104/0086709