The in vitro and in vivo stability studies on neutron-activated .sub.166 Ho-boromacroaggregates (BMA) and .sub.166 Ho-Poly(l-lactic acid)microspheres (PLA-MS)

0185222 - UJF-V 20010396 RIV DE eng J - Článek v odborném periodiku
Henková, K. - Kropáček, Martin - Melichar, František - Lang, O. - Kleisner, I.
The in vitro and in vivo stability studies on neutron-activated .sub.166 Ho-boromacroaggregates (BMA) and .sub.166 Ho-Poly(l-lactic acid)microspheres (PLA-MS).
European Journal of Nuclear Medicine. Roč. 27, č. 9 (2000), s. 1013. ISSN 0340-6997
Výzkumný záměr: CEZ:AV0Z1048901
Kód oboru RIV: BG - Jaderná, atomová a mol. fyzika, urychlovače
Impakt faktor: 3.772, rok: 2000

The radionuclide 166Ho is successfully produced in LWR-15 Nuclear research reactor at the Institute of Nuclear Research in Řež. Its physical properties (á-decay, the maximum á energy 1,84 MeV, half-time 26,8 d) are suitable for a plentyof medical applications, e.g. skin and hepatic malignancies, rheumatoid arthritis. 166Ho-BMA are obtained by irradiating of inactive 166Ho-BMA. These are prepared by reacting ofthe aqueous solution Ho(NO3)3 . 5H20 with 2,5 M sodium borohydride (NaBH4) solution in 0,2 M NaOH. The particle size distributions is 1 to 170 ćm. 166Ho-PLA-MS are obtained by irradiating of inacti ve 166Ho-PLA-MS. These are prepared by reacting of the aqueous solution Ho(AcAc)3 with chloroform solution poly(1-lactic acid). The acetylacetone complex of holmium is prepared by its precipitation into the aqueous phaseafter adding of the aqueous solution HoC13. 6 H20 to the aqueous solution NH4AcAc. The in vitro stability studies are carried out by incubating BMA in 6 ml of saline (various pH values) at either 37.sup.o C or 50.sup.o C for about 10 days.
Trvalý link: http://hdl.handle.net/11104/0081633