Measuring Transport of Water Across the Peritoneal Membrane

0181827 - UFCH-W 20030270 RIV GB eng J - Článek v odborném periodiku
Asghar, R. B. - Diskin, A. M. - Španěl, Patrik - Smith, D. - Davies, S. J.
Measuring Transport of Water Across the Peritoneal Membrane.
Kidney International. Roč. 64, - (2003), s. 1911-1915. ISSN 0085-2538. E-ISSN 1523-1755
Grant CEP: GA ČR GA202/03/0827
Výzkumný záměr: CEZ:AV0Z4040901
Klíčová slova: deuterium * total body water * solute transport
Kód oboru RIV: CF - Fyzikální chemie a teoretická chemie
Impakt faktor: 5.302, rok: 2003

Mechanisms of water flow across the peritoneal membrane include diffusion, convection and reabsorption. To understand these processes more clearly we have developed a method to measure transport of water across the peritoneal membrane. An artificial gradient of deuterated water (HDO) between blood and dialysate compartments was created in 5 subjects who took 0.3g per kg of body weight of D2O, which was allowed to equilibrate with total body water. During a test dwell (2L, bicarbonate:lactate buffer, 1.36% glucose to minimise convection), frequent dialysate samples were drawn to determine the abundance of deuterium and other solutes and to calculate their time constants. Dialysate deuterium abundance was measured using flowing afterglow mass spectrometry, FA-MS.
Trvalý link: http://hdl.handle.net/11104/0078342