Time Variation of Ammonia. Acetone, Isoprene and Ethanol in Breath: A Quantitative SIFT-MS Study over 30 Days

0181613 - UFCH-W 20030042 RIV GB eng J - Článek v odborném periodiku
Diskin, A. M. - Španěl, Patrik - Smith, D.
Time Variation of Ammonia. Acetone, Isoprene and Ethanol in Breath: A Quantitative SIFT-MS Study over 30 Days.
Physiological Measurement. Roč. 24, - (2003), s. 107-119. ISSN 0967-3334. E-ISSN 1361-6579
Grant CEP: GA ČR GA203/00/0632; GA ČR GA203/02/0737
Výzkumný záměr: CEZ:AV0Z4040901
Klíčová slova: SIFT-MS study * acetone * isoprene
Kód oboru RIV: CF - Fyzikální chemie a teoretická chemie
Impakt faktor: 1.159, rok: 2003

A study of the concentrations of the common breath metabolites ammonia, acetone, isoprene, ethanol and acetaldehyde in the breath of five subjects over a period of 30 days has been carried out. Breath samples were taken and analysed in the early morning on arrival at the laboratory. The real time analyses of three consecutive breath exhalations were carried out using selected ion flow tube mass spectrometry (SIFT-MS) on line to the instrument. Sufficient data were obtained to allow meaningful concentration distributions to be obtained for ammonia, acetone, isoprene and ethanol. These showed that the ammonia, acetone and isoprene concentrations exhibited sensibly normal distributions, with coefficients of variation of typically 0.3. Obvious and statistically significant (p < 0.01) differences are apparent in the mean concentrations of these metabolites between the five individuals. The acetaldehyde concentrations were relatively low and close to the instrument detection limit.
Trvalý link: http://hdl.handle.net/11104/0078152