Human Monitoring for Genetic Effects

0173768 - UEM-P 20033092 RIV GB eng M - Část monografie knihy
Rössner ml., Pavel - Binková, Blanka - Chvátalová, Irena - Šrám, Radim
The effect of acrylonitrile exposure on the expression of p53 and p21WAF1 proteins in the blood plasma of occupationally exposed workers and in human diploid lung fibroblasts.
Human Monitoring for Genetic Effects. Amsterdam: IOS Press, 2003 - (Cebulska-Wasilewska, A.; Au, W.; Šrám, R.), s. 262. NATO Sci. Series I., 351
Grant CEP: GA MŠMT OK 390; GA ČR GP310/01/P030
Grant ostatní: EC(XE) IC 15-CT97-0302
Výzkumný záměr: CEZ:AV0Z5039906
Klíčová slova: acrylonitrile * occupational exposure * p53 protein
Kód oboru RIV: EB - Genetika a molekulární biologie

The effect of exposure to acrylonitrile (ACN) on the expression of p53 and p21WAF1 proteins in blood serum of acrylonitrile-exposed workers from petrochemical industry was evaluated. The expression of both proteins was determined by ELISA immunoassay and western blotting. ACN induced also the expression of heat shock proteins hsp32 and hsp70 which may be sensitive biomarkers of environmental pollution.
Trvalý link: http://hdl.handle.net/11104/0070794