Cyclin D-cdk6 complex is targeted by p21WAF in growth-arrested lymphoma cells

0173635 - UEM-P 20023085 RIV US eng J - Článek v odborném periodiku
Tvrdík, Daniel - Djaborkhel, Rashed - Nagy, Alexandr - Eckschlager, T. - Raška, Ivan - Müller, Julius
Cyclin D-cdk6 complex is targeted by p21WAF in growth-arrested lymphoma cells.
Journal of Structural Biology. Roč. 140, - (2002), s. 49-56. ISSN 1047-8477. E-ISSN 1095-8657
Grant CEP: GA ČR GA304/01/0564
Výzkumný záměr: CEZ:AV0Z5039906; CEZ:MSM 111100003
Klíčová slova: cyclin-dependent kinase * follicular lymphoma * retinoblastoma protein
Kód oboru RIV: EA - Morfologické obory a cytologie
Impakt faktor: 4.194, rok: 2002

The kinase activity of cdk2, cdk4, and cdk6 was significantly reduced and hypophosphorylation of pRb on serine 795 (S795) and threonine 373 (T373) was observed. Both cdk4 and cdk6 were notably dissociated from cyclin D co-factors, while cyclin E-cdk2 complexes remained coupled in TGFß1-treated cells. TGFß1-induced growth arrest was associated with notably increased binding of p21WAF1 to cdk4 and cdk6.
Trvalý link: http://hdl.handle.net/11104/0070664