Quinolinic Acid - Iron(II) Complexes: Slow Autoxidation, but Enhanced Hydroxyl Radical Production in the Fenton Reaction

0163268 - UACH-T 20013139 RIV GB eng J - Článek v odborném periodiku
Pláteník, J. - Stopka, Pavel - Vejražka, M. - Štípek, S.
Quinolinic Acid - Iron(II) Complexes: Slow Autoxidation, but Enhanced Hydroxyl Radical Production in the Fenton Reaction.
Free Radical Research. Roč. 34, č. 5 (2001), s. 445-459. ISSN 1071-5762. E-ISSN 1029-2470
Grant CEP: GA ČR GA203/97/0642; GA ČR GA309/99/0211
Výzkumný záměr: CEZ:AV0Z4032918
Klíčová slova: iron chelator * reactive oxygen species * excitotoxicity
Kód oboru RIV: CA - Anorganická chemie
Impakt faktor: 2.735, rok: 2001

Quinolinate (pyridine-2,3-dicarbolic acid, Quin) is a neurotoxic tryptophan metabolite produced mainly by immune-activated macrophages. It is implicated in the pathogenesis of several brain disorders including HIV-associated dementia. Previous evidence suggests that Quin may exert its neurotoxic effects not only as an agonist on the NMDA subtype of glutamate receptor, but also by a receptor-independent mechanism. In this study we address ability of ferrous quinolinate chelates to generate reactive ox n species.
Trvalý link: http://hdl.handle.net/11104/0060521