0162188 - UIACH-O 200007 RIV DE eng J - Článek v odborném periodiku
Procházková, Andrea - Chouki, M. - Theurillat, R. - Thormann, W.
Therapeutic drug monitoring of albendazole: Determination of albendazole, albendazole sulfoxide, and albendazole sulfone in human plasma using nonaqueous capillary electrophoresis.
Electrophoresis. Roč. 21, č. 4 (2000), s. 729-736. ISSN 0173-0835. E-ISSN 1522-2683
Výzkumný záměr: CEZ:AV0Z4031919
Kód oboru RIV: CB - Analytická chemie, separace
Impakt faktor: 3.385, rok: 2000

A nonaqueous capillary electrophoresis (NACE) for the fast determination of plasma levels of albendazole, albendazole sulfoxide, and albendazole sulfone is described. The assay is based upon liquid/liquid extraction of these compounds using dichlormethane (pH 10.2), followed by a NACE separation performed using a 0.036 M borate buffer (apparent pH 9.9) in a mixture of methanol and N-methylformamide (1:3) and on-column absorbance detection at 280 nm. The reliability of the method developed was verified via analysis of 45 plasma samples obtained from patients treated with albendazole.
Trvalý link: http://hdl.handle.net/11104/0059508