Comparison of the significance of CD4+ and CD8+ T lymphocytes in the protection of mice against Encephalitozoon cuniculi infection

0157566 - PAU-O 20023041 RIV US eng J - Článek v odborném periodiku
Braunfuchsová, Pavlína - Salát, Jiří - Kopecký, Jan
Comparison of the significance of CD4+ and CD8+ T lymphocytes in the protection of mice against Encephalitozoon cuniculi infection.
Journal of Parasitology. Roč. 88, č. 4 (2002), s. 797-799. ISSN 0022-3395. E-ISSN 1937-2345
Grant CEP: GA AV ČR IAA6022101
Výzkumný záměr: CEZ:AV0Z6022909
Klíčová slova: immune response * interferon gamma * microsporidiosis
Kód oboru RIV: EC - Imunologie
Impakt faktor: 1.336, rok: 2002

The role of T lymphocyte subpopulations in the protection against intraperitoneal (i.p.) and peroral Encephalitozoon cuniculi infections was compared in adoptive-transfer experiments using severe combined immunodeficient mice. Whereas CD8+ T cell-depleted, but not CD4+ T cell-depleted, BALB/c splenocytes failed to protect the mice against i.p. infection, only SCID mice reconstituted with both CD4+ T lymphocyte- and CD8+ T lymphocyte-depleted splenocytes succumbed to peroral infection. The results indicate that whereas CD8+ T cells are critical for the protection against an i.p. E. cuniculi infection, both CD4+ and CD8+ T lymphocyte subpopulations play a substantive protective role in a peroral infection, i.e., natural route of infection.
Trvalý link: http://hdl.handle.net/11104/0055004