Hypertensive response to chronic NG-nitro-L-arginine methyl ester (L-NAME) treatment is similar in immature and adult Wistar rats

0142504 - FGU-C 20030128 RIV GB eng J - Článek v odborném periodiku
Zicha, Josef - Pecháňová, O. - Dobešová, Zdenka - Kuneš, Jaroslav
Hypertensive response to chronic NG-nitro-L-arginine methyl ester (L-NAME) treatment is similar in immature and adult Wistar rats.
Clinical science. Roč. 105, č. 4 (2003), s. 483-489. ISSN 0143-5221. E-ISSN 1470-8736
Grant CEP: GA ČR GA305/03/0769; GA MZd NB6682; GA MŠMT LN00A069
Grant ostatní: VEGA(SK) 2/3185/23; SAV(SK) APVT51-017902
Výzkumný záměr: CEZ:AV0Z5011922
Klíčová slova: nitric oxide * L-NAME hypertension * age-dependent susceptibility
Kód oboru RIV: FA - Kardiovaskulární nemoci vč. kardiochirurgie
Impakt faktor: 2.117, rok: 2003

The same blood pressure rise was demonstrated in young and adult L-NAME treated rats in hich a similar degree of NO synthesis inhibition was disclosed. This suggests that altered NO bioavailability (but not the generally exaggerated reactivity to hypertensive stimuli) is the cause of greater blood pressure response of immature than adult rats to chronic excess salt intake.
Trvalý link: http://hdl.handle.net/11104/0040206