Počet záznamů: 1
Fos expression in spinothalamic and postsynaptic dorsal column neurons following noxious visceral and cutaneous stimuli
- 1.0142477 - FGU-C 20030091 RIV NL eng J - Článek v odborném periodiku
Paleček, Jiří - Palečková, V. - Willis, W. D.
Fos expression in spinothalamic and postsynaptic dorsal column neurons following noxious visceral and cutaneous stimuli.
Pain. Roč. 104, 1-2 (2003), s. 249-257. ISSN 0304-3959. E-ISSN 1872-6623
Grant CEP: GA ČR GA309/03/0752
Grant ostatní: NIH(US) NS09743; NIH(US) NS11255
Výzkumný záměr: CEZ:AV0Z5011922
Klíčová slova: visceral pain * myelotomy * postsynaptic dorsal column
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
Impakt faktor: 4.556, rok: 2003
Fos protein expression in retrogradely labeled spinothalamic tract (STT) and postsynaptic dorsal column (PSDC) neurons in the lumbosacral enlargement in rats was used as an anatomical marker of enhanced activation to compare the role of these neurons in cutaneous and visceral pain. The noxious stimuli used were intradermal injection of capsaicin and distention of the ureter. Retrogradely labeled neurons were found in laminae III-IV and in the vicinity of the central canal. STT neurons were located in laminae I, III-VII and X. Ureter distention evoked Fos expression in PSDC and STT neurons located in all laminae in which retrogradely labeled cell were found, with the maximum in the L2 spinal segment. The Fos-positive PSDC neurons represented a significantly higher percentage of the retrogradely labeled neurons than of the STT Fos-positive neurons. Intradermal capsaicin injection also evoked Fos expression in both PSDC and STT neurons, but with no significant difference between these two. These results show that both PSDC and STT neurons are activated by cutaneous and visceral noxious stimuli.
Trvalý link: http://hdl.handle.net/11104/0040180
Počet záznamů: 1